Neuroprotective agents for neonatal hypoxic–ischemic brain injury
نویسندگان
چکیده
منابع مشابه
Neuroprotective agents for neonatal hypoxic-ischemic brain injury.
Hypoxic-ischemic (H-I) brain injury in newborns is a major cause of morbidity and mortality that claims thousands of lives each year. In this review, we summarize the promising neuroprotective agents tested on animal models and pilot clinical studies of neonatal H-I brain injury according to the different phases of the disease. These agents target various phases of injury including the early ph...
متن کاملNeuroprotective role of nerve growth factor in hypoxicischemic injury. From brain to skin.
Hypoxic-ischemic injuries (HII) of the brain, optic pathways, and skin are frequently associated with poor neurological and clinical outcome. Unfortunately, no new therapeutic approaches have been proposed for these conditions. Recently, experimental and clinical studies showed that nerve growth factor (NGF) can improve neurological deficits, visual loss and skin damage after HII. Based on thes...
متن کاملNeuroprotective effect of Bax-inhibiting peptide on neonatal brain injury.
BACKGROUND AND PURPOSE Mitochondria play a critical role in mediating cell death in both the adult and immature brain. The cyclophilin D mitochondrial membrane permeability transition pore is critical in adult ischemia, whereas in neonatal hypoxic-ischemic (HI) brain injury, mitochondrial permeabilization appears to be primarily Bax-dependent. The aim of this study was to evaluate the neuroprot...
متن کاملNeuroprotective strategies for the neonatal brain.
Injury to the perinatal brain is a leading cause of childhood mortality and lifelong disability. Cerebral palsy and cognitive impairment are usually related to periventricular white matter damage, which is seen chiefly in babies born before 32 wk gestational age, and to corticosubcortical lesions, which occur mainly in full-term infants. Despite recent improvements in neonatal care, no effectiv...
متن کاملNeuroprotective strategies for traumatic brain injury
Head trauma is a common event that often causes traumatic brain injury (TBI). Following the acute mechanical insult, TBI evolves over the ensuing minutes and days. Understanding the secondary factors that contribute to TBI might suggest therapeutic strategies to reduce the long-term consequences of brain trauma. To assess secondary factors that contribute to TBI, we studied a fluid percussion i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Discovery Today
سال: 2015
ISSN: 1359-6446
DOI: 10.1016/j.drudis.2015.09.001